PF-06869206
| CAS号 | 2227425-05-8 | 货号 | BCP31135 |
| 中文名 | PF-06869206 | ||
| 英文名 | PF-06869206 | ||
| 中文别名 | |||
| 英文别名 | PF 06869206; PF06869206; | ||
| 分子式 | C15H14ClF3N4O2 | 分子量 | 374.74 |
| 生物活性 | PF-06869206 is an Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). PF-06869206 is the first orally bioavailable selective NaPi2a inhibitor and, as such, represents a pharmacological tool to probe the functional effects of selective NaPi2a inhibition in vivo. PF-06869206 showed a balance of attributes with 380 nM NaPi2a inhibition potency, excellent subtype selectivity, and acceptable aqueous solubility (46 μM). Furthermore, permeability is good (14 × 10−6 cm/s), and RLM clearance is low (<14 μL/min/mg; HLM = 39 μL/min/mg). | ||
| 信号通路 | Ion Channel/Membrane Transporter Others Pathway | ||
| 靶 点 | Sodium Channel Others | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！