TR-14035
CAS号 | 232271-19-1 | 货号 | BCP30639 |
中文名 | TR-14035 | ||
英文名 | TR-14035 | ||
中文别名 | |||
英文别名 | TR 14035; TR14035;MDK-1191; MDK1191; MDK 1191; SB683698; SB 683698; SB-683698; QJ-2620; | ||
分子式 | C24H21Cl2NO5 | 分子量 | 474.33 |
生物活性 | TR14035 blocked the binding of human alpha(4)beta(7) to an (125)I-MAdCAM-Ig fusion protein with IC(50) values of 0.75 nM. TR14035 blocked binding of human alpha(4)beta(7)-expressing RPMI-8866 cells or murine mesenteric lymph node lymphocytes to MAdCAM-Ig with IC(50) values of 0.1 microM. TR14035 blocked adhesion to HEVs [ED(50) of 0.01-0.1 mpk i.v.]. TR-14035 was taken up by rat and human hepatocytes by an apparently single saturable mechanism with K(m) of 6.7 and 2.1 microM, respectively, and taurocholate and digoxin reduced this uptake. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | Integrin |
结构式
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