T-3775440
| CAS No. | 1422620-34-5 | Cat. No. | BCP30535 |
| Name | T-3775440 | ||
| Synonyms | T 3775440;T3775440; | ||
| Formula | C18H22N4O | M. Wt | 310.40 |
| Description | T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Demethylase | ||
Structure
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