蓝萼甲素
CAS号 | 79498-31-0 | 货号 | BCP30380 |
中文名 | 蓝萼甲素 | ||
英文名 | Glaucocalyxin A | ||
中文别名 | |||
英文别名 | LeukaMenin F; Wangzaozin B; Leucamenin F; | ||
分子式 | C20H28O4 | 分子量 | 332.43 |
生物活性 | Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. | ||
信号通路 | Protease/Metabolic Enzyme | ||
靶 点 | Caspase |
结构式
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