C25-140
CAS号 | 1358099-18-9 | 货号 | BCP30323 |
中文名 | C25-140 | ||
英文名 | C25-140 | ||
中文别名 | |||
英文别名 | C25140; C25 140;TRAF6-Ubc13 inhibitor C25-140; | ||
分子式 | C26H31N7O | 分子量 | 457.58 |
生物活性 | C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity; C25-140 effectively reduced TRAF6-mediated ubiquitin chain formation in vitro, impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells; does not effect other E3 ligases (MDM2, TRIM63, ITCH, E6AP and RNF4), also does inhibit E1/E2 reactions. | ||
信号通路 | Protease/Metabolic Enzyme Apoptosis Pathway | ||
靶 点 | E1 E2 E3 Enzyme TNF Receptor |
结构式
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