MK-8722
CAS号 | 1394371-71-1 | 货号 | BCP30296 |
中文名 | MK-8722 | ||
英文名 | MK-8722 | ||
中文别名 | |||
英文别名 | MK 8722; MK8722; | ||
分子式 | C24H20ClN3O4 | 分子量 | 449.89 |
生物活性 | MK-8722 is a potent pan-AMPK activator. MK-8722 improves glucose homeostasis but induces cardiac hypertrophy. In rodents and rhesus monkeys, MK-8722-mediated AMPK activation in skeletal muscle induced robust, durable, insulin-independent glucose uptake and glycogen synthesis, with resultant improvements in glycemia and no evidence of hypoglycemia. These effects translated across species, including diabetic rhesus monkeys, but manifested with concomitant cardiac hypertrophy and increased cardiac glycogen without apparent functional sequelae. | ||
信号通路 | PI3K/Akt/mTOR Epigenetics | ||
靶 点 | AMPK |
结构式
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