LXH254 HCl
| CAS No. | LXH254HCl | Cat. No. | BCP30244 |
| Name | LXH254 HCl | ||
| Synonyms | LXH-254 HCl ;LXH 254 HCl ; LXH254 hydrochloride; LXH-254 hydrochloride; LXH 254 hydrochloride; | ||
| Formula | C25H26ClF3N4O4 | M. Wt | 538.95 |
| Description | LXH254 is an orally available inhibitor of all members of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon administration, pan-RAF inhibitor LXH254 binds to Raf proteins and inhibits Raf-mediated signal transduction pathways. This inhibits proliferation of Raf-overexpressing tumor cells. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. | ||
| Pathways | MAPK Pathway | ||
| Targets | Raf | ||
Structure
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