KU 60019
| CAS号 | 925701-46-8 | 货号 | BCP30241 |
| 中文名 | KU 60019 | ||
| 英文名 | KU 60019 | ||
| 中文别名 | |||
| 英文别名 | KU-60019;KU60019; | ||
| 分子式 | C30H33N3O5S | 分子量 | 547.68 |
| 生物活性 | KU-60019 is a potent and reversible inhibitor of ATM kinase with IC50 of 6.3 nM. It is an improved analogue of KU-55933. It exhibits little to no nonspecific target effects against a panel of 229 protein kinases and displays similar target selectivity to KU 55933. It blocks the phosphorylation of ATM substrate proteins. It sensitizes glioma cells to radiation and also sensitizes the normal fibroblasts but not the A-T fibroblasts to radiation. It inhibits migration and invasion of glioma cells in vitro. | ||
| 信号通路 | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| 靶 点 | ATM/ATR | ||
结构式
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