AZD1390
| CAS号 | 2089288-03-7 | 货号 | BCP28994 |
| 中文名 | AZD1390 | ||
| 英文名 | AZD1390 | ||
| 中文别名 | |||
| 英文别名 | AZD-1390; AZD 1390; | ||
| 分子式 | C27H32FN5O2 | 分子量 | 477.58 |
| 生物活性 | AZD1390 is a potent and selective ATM inhibitor with the ability to cross the blood-brain barrier suitable for the treatment of intracranial malignancies.AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50 = 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases. AZD1390 displays excellent oral bioavailability in preclinical species (66% in rat and 74% in dog), is not a substrate for human efflux transporters, and has been shown to efficiently cross the BBB in non-human primate PET studies. | ||
| 信号通路 | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| 靶 点 | ATM/ATR | ||
结构式
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