COTI-2
  • 化学数据
CAS号 1039455-84-9 货号 BCP28961
中文名 COTI-2
英文名 COTI-2
中文别名
英文别名 COTI2; COTI 2;
分子式 C19H22N6S 分子量 366.48
  • 用途
生物活性 COTI-2 is an P53 gene modulator and AKT2 inhibitor. OTI-2 is active against multiple human cancer cell lines in vitro and in vivo. COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines. COTI-2 is currnelty in clinical trials. Importantly, no overt toxicity was observed in the combination treatment groups in vivo. Furthermore, unlike the tested chemotherapeutic drugs, cancer cells did not develop resistance to COTI-2. Finally, some chemo-resistant tumor cell lines only showed mild cross-resistance to COTI-2 while most remained sensitive to it.
信号通路 Apoptosis Pathway 
靶 点 p53 

结构式

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