OG-L002 hydrochloride
| CAS No. | 1357298-75-9 | Cat. No. | BCP25948 |
| Name | OG-L002 hydrochloride | ||
| Synonyms | OG-L002 HCl; OG L002 HCl; OGL002 HCl; OG L002 Hydrochloride; OGL002 Hydrochloride; | ||
| Formula | C15H16ClNO | M. Wt | 261.75 |
| Description | OG-L002 HCl is a highly specific inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A, or H3K9 demethylase) (IC50, ~0.02 µM). OG-L002 potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. It suppressed primary lytic infection of HSV in vivo in a mouse model. This highlights the potential for drugs that inhibit a virus’ ability to modify chromatin for treating or even preventing viral diseases like herpes, chicken pox, and shingles. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Demethylase | ||
Structure
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