VXc-486
| CAS号 | 1384984-18-2 | 货号 | BCP20714 |
| 中文名 | VXc-486 | ||
| 英文名 | VXc-486 | ||
| 中文别名 | |||
| 英文别名 | VXc486 ;VXc 486; | ||
| 分子式 | C21H25FN6O3 | 分子量 | 428.46 |
| 生物活性 | VXc-486, which targets gyrase B, potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis in vitro (MICs of 0.03 to 0.30 ug/ml and 0.08 to 5.48 u g/ml, respectively) and reduces mycobacterial burdens in lungs of infected mice in vivo.VXc-486 is active against drug-resistant isolates, has bactericidal activity, and kills intracellular and dormant M. tuberculosis bacteria in a low-oxygen environment. Furthermore, VXc-486 inhibits the growth of multiple strains of M.abscessus, M. avium complex, and M. kansasii (MICs of 0.1 to 2.0 u g/ml), as well as that of several strains of Nocardia spp. (MICs of 0.1 to 1.0 u g/ml). | ||
| 信号通路 | Microbiology/Virology Cell Cycle/DNA Damage | ||
| 靶 点 | Topoisomerase Antibiotic | ||
结构式
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