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Topoisomerase

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Topoisomerase

Chemical Structure Cat. No. Product Name CAS No.
SN-38-D3 Chemical Structure
 BCP49629 SN-38-D3 718612-49-8
SN-38-D3 is the deuterium labeled SN-38. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan.
Irinotecan sucrosofate Chemical Structure
 BCP49278 Irinotecan sucrosofate 1361317-83-0
Irinotecan is a camptothecin analog and topoisomerase I inhibitor.
Voreloxin Hydrochloride Chemical Structure
 BCP49069 Voreloxin Hydrochloride 175519-16-1
Voreloxin hydrochloride is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity.
Levofloxacin hydrochloride Chemical Structure
 BCP24629 Levofloxacin hydrochloride 177325-13-2
Levofloxacin hydrochloride is a fluoroquinolone antibiotic inhibitor of DNA gyrase and topoisomerase IV.
Indimitecan Chemical Structure
 BCP46636 Indimitecan 915360-05-3
Indimitecan is a novel topoisomerase I inhibitor.
AZD-5099 Chemical Structure
 BCP46609 AZD-5099 907543-25-3
AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.
Bisantrene dihydrochloride Chemical Structure
 BCP46265 Bisantrene dihydrochloride 71439-68-4
Bisantrene Hydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.
ARN-21934 Chemical Structure
 BCP44949 ARN-21934 2230854-93-8
ARN-21934 is a novel potent and highly selective inhibitor for human topoisomerase II α over β.
Berubicin Chemical Structure
 BCP41505 Berubicin 677017-23-1
Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, and RNA and protein synthesis.
Rebeccamycin Chemical Structure
 BCP41470 Rebeccamycin 93908-02-2
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I.
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