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S1P Receptor

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S1P Receptor

Chemical Structure Cat. No. Product Name CAS No.
CYM-5478 Chemical Structure
 BCP49679 CYM-5478 870762-83-7
CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity.
BMS-986278 Chemical Structure
 BCP45657 BMS-986278 2170126-74-4
BMS-986278, a second-generation LPA1 antagonist, is currently in phase 2 development as a therapy for IPF and PF-ILD.
TY-52156 Chemical Structure
 BCP45353 TY-52156 934369-14-9
TY-52156 is a potent and selective S1P3 receptor antagonist with a Ki value of 110 nM.
CYM50358 Chemical Structure
 BCP44572 CYM50358 1314212-39-9
CYM50358 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4).
MUN96006 Chemical Structure
 BCP42260 MUN96006 2130996-00-6
MUN96006 is an antagonists of sphingosine-​1-​phosphate (S1P) receptor for prophylaxis and​/or treatment of diseases including fibrotic, inflammatory, autoimmune, metabolic, cardiovascular, and​/or proliferative diseases.
S1P1 Agonist III Chemical Structure
 BCP41026 S1P1 Agonist III 1324003-64-6
S1P1 Agonist III is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonist.
PF429242 dihydrochloride Chemical Structure
 BCP39849 PF429242 dihydrochloride 2248666-66-0
PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism.
W146 trifluoroacetate salt Chemical Structure
 BCP38982 W146 trifluoroacetate salt 909725-62-8
W146 is a potent, selective S1P1 antagonist with Ki of 18 nM, displays no effect at S1P2, S1P3 or S1P5, enhances capillary leakage and restores lymphocyte egress in vivo. .
RP101075 Chemical Structure
 BCP38980 RP101075 1306760-73-5
RP101075 is a metabolite of ozanimod (GLXC-10658), exhibiting a similar specificity profile as ozanimod at the S1P receptor family in vitro and pharmacodynamic profile in vivo
VPC 23019 Chemical Structure
 BCP37989 VPC 23019 449173-19-7
VPC 23019 is an aryl amide-containing S1P analog that acts as a competitive antagonist, inhibit S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.
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