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Phospholipase

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Phospholipase

Chemical Structure Cat. No. Product Name CAS No.
Varespladibmethyl Chemical Structure
 BCP48475 Varespladibmethyl 172733-08-3
Varespladib methyl is a selective inhibitor of group II secretory phospholipase A2 (PLA2).
SB-435495 Chemical Structure
 BCP45093 SB-435495 304694-39-1
SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM.
ML298 Chemical Structure
 BCP37987 ML298 1426916-02-0
ML-298 is a potent inhibitor of phospholipase D2 (PLD2) displaying selectivity for PLD2 over PLD1 with IC50 values of 355 and 20000 nM, respectively.
ML349 Chemical Structure
 BCP37902 ML349 890819-86-0
ML 349 is a lysophospholipase 2 inhibitor with IC50 value of 144 nM.
ML-299 Chemical Structure
 BCP37841 ML-299 1426916-00-8
ML-299 is a dual PLD1/2 inhibitor (PLD1 IC50 = 6 nM, PLD2 IC50 = 20 nM).
YM 26734 Chemical Structure
 BCP37836 YM 26734 144337-18-8
YM-26734 is an inhibitor of rabbit platelet sPLA2.
Aacocf3 Chemical Structure
 BCP33391 Aacocf3 149301-79-1
AACOCF3 is a fatty acid derivative that is arachidonic acid in which the OH part of the carboxy group has been replaced by a trifluoromethyl group
CAY10650 Chemical Structure
 BCP32595 CAY10650 1233706-88-1
CAY10650 is a potent cPLA2a inhibitor, demonstrating strong anti-inflammatory effects.
N-(p-amylcinnamoyl) Anthranilic Acid Chemical Structure
 BCP30845 N-(p-amylcinnamoyl) Anthranilic Acid 110683-10-8
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia.
CAY10594 Chemical Structure
 BCP30751 CAY10594 1130067-34-3
CAY10594 is a potent PLD2 inhibitor, both in vitro (IC50 = 140 nM) and in cells (IC50 = 110 nM). It is also effective as a PLD1 inhibitor at higher concentrations (IC50 = 5.1 μM in vitro, 1.0 μM in cells). CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.
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