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NFκB

Chemical Structure Cat. No. Product Name CAS No.
CAY10576 Chemical Structure
 BCP24906 CAY10576 862812-98-4
CAY10576 is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM.
Edasalonexent Chemical Structure
 BCP25138 Edasalonexent 1204317-86-1
Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.
Vamorolone Chemical Structure
 BCP47443 Vamorolone 13209-41-1
Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent NF-κB inhibition and substantially reduces hormonal effects.
Sodium salicylate Chemical Structure
 BCP47031 Sodium salicylate 54-21-7
Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
IMD-0560 Chemical Structure
 BCP46800 IMD-0560 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
Sappanone A Chemical Structure
 BCP46467 Sappanone A 102067-84-5
Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.
SM-7368 Chemical Structure
 BCP46452 SM-7368 380623-76-7
SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner. SM-7368 strongly inhibits the TNF-alpha-induced invasion of HT1080 human fibrosarcoma cell line.
NDMC101 Chemical Structure
 BCP46451 NDMC101 1308631-40-4
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.
WAY-204688 Chemical Structure
 BCP46376 WAY-204688 796854-35-8
WAY-204688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50: 122 ± 30 nM for NF-κB-luciferase in HAECT-1 cells).
Nrf2 activator-1 Chemical Structure
 BCP45478 Nrf2 activator-1 2230697-41-1
Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2).
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