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MAP4K

Chemical Structure Cat. No. Product Name CAS No.
HPK1-IN-22 Chemical Structure
 BCP35846 HPK1-IN-22 2380300-79-6
HPK1-IN-22 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein.
MAP4K4-IN-3 Chemical Structure
 BCP46896 MAP4K4-IN-3 1811510-58-3
MAP4K4-IN-3 may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
HPK1-IN-7 Chemical Structure
 BCP43399 HPK1-IN-7 2320462-65-3
HPK1-IN-7 is a potent, orally active HPK1 inhibitor.
GNE-495 Chemical Structure
 BCP36075 GNE-495 1449277-10-4
GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.
TAK1/MAP4K2 inhibitor 1 Chemical Structure
 BCP21395 TAK1/MAP4K2 inhibitor 1 1315330-11-0
TAK1/MAP4K2 inhibitor 1 is a B-Raf inhibitor, pyrazine and pyrrolo[2,3-b]pyridine derivatives, useful in the treatment of cancer and proliferative diseases.
DMX-5084 Chemical Structure
 BCP30841 DMX-5084 2306178-56-1
DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor.
HG6-64-1 Chemical Structure
 BCP11080 HG6-64-1 1315329-43-1
HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor.HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively.
PF-06260933 Chemical Structure
 BCP28968 PF-06260933 1811510-56-1
PF-06260933 is a potent and highly selective inhibitor of MAP4K4.
PF-06260933 dihydrochloride Chemical Structure
 BCP28969 PF-06260933 dihydrochloride 1883548-86-4
PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.
PF-06260933 HCl Chemical Structure
 BCP28970 PF-06260933 HCl 2118243-34-6
PF-06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM).
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