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Kinesin

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Kinesin

Chemical Structure Cat. No. Product Name CAS No.
Paprotrain Chemical Structure
 BCP46472 Paprotrain 57046-73-8
Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
CW069 Chemical Structure
 BCP27898 CW069 1594094-64-0
CW-069 is a novel and allosteric inhibitor of the microtubule motor protein HSET, it shows statistically significant selectivity over KSP.
MK-0731 Chemical Structure
 BCP30541 MK-0731 845256-65-7
MK-0731 is a synthetic small molecule with potential antineoplastic activity.
AZD4877 Chemical Structure
 BCP07430 AZD4877 1176760-49-8
AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity.
ARQ 621 Chemical Structure
 BCP28395 ARQ 621 1095253-39-6
ARQ-621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division.
Dimethylenastron Chemical Structure
 BCP17179 Dimethylenastron 863774-58-7
Dimethylenastron is an Eg5 inhibitor, which arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
EMD 534085 Chemical Structure
 BCP03745 EMD 534085 858668-07-2
EMD534085 is a kinesin inhibitor currently in clinical development.
Monastrol Chemical Structure
 BCP06757 Monastrol 329689-23-8
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
Monastrol Chemical Structure
 BCP19385 Monastrol 254753-54-3
Monastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint.
SB-715992 Chemical Structure
 BCP02454 SB-715992 587881-28-5
Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A.
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