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5 HT Receptor/Serotonin Receptor

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5 HT Receptor/Serotonin Receptor

Chemical Structure Cat. No. Product Name CAS No.
Pipamperone dihydrochloride Chemical Structure
 BCP49191 Pipamperone dihydrochloride 2448-68-2
Pipamperone acts as an antagonist of the 5-HT2A, 5-HT2B, 5-HT2C D2, D3, D4, α1-adrenergic, and α2-adrenergic receptors. It shows much higher affinity for the 5-HT2A and D4 receptors over the D2 receptor (15-fold in the case of the D4 receptor, and even higher in the case of the 5-HT2A receptor), being regarded as "highly selective" for the former two sites at low doses. Pipamperone has low and likely insignificant affinity for the H1 and mACh receptors, as well as for other serotonin and dopamine receptors.
Temanogrel Chemical Structure
 BCP24269 Temanogrel 887936-68-7
Temanogrel is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.
NAS-181 methanesulfonate Chemical Structure
 BCP49052 NAS-181 methanesulfonate 205242-62-2
NAS-181 methanesulfonate is a 5-HT(1B) receptor antagonist.
Sarizotan Chemical Structure
 BCP24751 Sarizotan 351862-32-3
Sarizotan is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively.
Opiranserin Chemical Structure
 BCP48961 Opiranserin 1441000-45-8
Opiranserin is a glycine transporter inhibitor and serotonin receptor antagonist. Opiranserin is a drug candidate.
DOI hydrochloride Chemical Structure
 BCP25643 DOI hydrochloride 42203-78-1
DOI hydrochloride is a brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.
8-OH-Dpat Chemical Structure
 BCP25681 8-OH-Dpat 78950-78-4
8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
Prucalopride hydrochloride Chemical Structure
 BCP48408 Prucalopride hydrochloride 179474-80-7
Prucalopride hydrochloride is a selective 5-HT4 agonist.
RU-24969 Chemical Structure
 BCP48648 RU-24969 66611-26-5
RU-24969 is a potent, selective agonist of 5-HT1A and 5-HT1B receptors, with preference for 5-HT1B.
(Z)-Thiothixene Chemical Structure
 BCP48214 (Z)-Thiothixene 3313-26-6
Thiothixene is a modulator of human P-glycoprotein and is frequently used a an anti-psychotic.
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